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CV Garvin

Michael R. Garvin, Ph.D.

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972 58-628-8612*

Current Positions

Post-doctoral Fellow, University of Haifa

Identification of the genetic basis of the adaptation of fire salamanders (Salamandra inframmaculata and S. salamandra) to different environments in Israel and Germany. My role is to work with Alan Templeton and Sharlee Climer from Washington University in Saint Louis, Leon Blaustein at the University of Haifa, Arne Notle at the Max Plank Institute in Plon, and Sebastian Steinfartz at the University of Braunschweig to analyze the gene expression profiles of wild animals from both locations to determine if adaptation is due to plasticity or genetics.

Associate Research Professor, Washington State University

Working with Gary Thorgaard and other WSU faculty to identify the role of mitochondrial- and nuclear-encoded genes in development rate of rainbow trout. We are also focused on bioenergetics and functional genomics using Thorgaard's double haploid system of clonal fish.

Several molecular genetic projects as collaborative efforts with ADF&G, the City and Borough of Yakutat, and Bruce Finney at Idaho State University. Population structure and paleo-genetics of Pacific salmon with environmental and ancient DNA (eDNA and aDNA), invasive species detection in Alaskan drainages, assay development, and genetic marker development including next-generation sequencing.

Education

Ph. D. 2012 University of Alaska Fairbanks

M.S. 2009 University of Alaska Fairbanks

B.S. 1991 University of Washington

Previous Research Experience

Post-doctoral Fellow, University of Alaska Fairbanks (2012-2014)

Leading a collaborative project between UAF, federal, state, and tribal entities to identify genetic markers that show divergence among western Alaskan chum salmon populations with next-generation sequencing and other new technology.

Building on a structural and functional model of a protein complex that has experienced positive selection during the evolution of diverse taxa. Prediction of functional changes that result from amino acid substitutions among species and populations that inhabit different environments. This is a collaborative effort with Dr. Joe Beielawski at Dalhousie University, Dr. A.J. Gharrett at UAF, and Dr. Leonid Sazanov at the Mitochondrial Biology Unit at Cambridge University in the U.K.

Guest lecturer in general genetics and conservation biology

Research Associate, Tularik, Inc, (Now Amgen) (2001-2004)

Assessment and use of gene expression technologies to develop drugs to treat metabolic disorders and cancer including RNAi, qPCR, and cDNA microarrays. I developed a system to rapidly screen cancer cell lines for duplicated genes, which was expanded after Tularik was acquired by Amgen.

Research Associate, CV Therapeutics, Inc. (Now Gilead Biosciences) (1998-2001)

Development of novel technology to measure expression of genes associated with cardiovascular disease. I identified the mutations in the gene ABCA1 with microarray technology and provided this as a candidate gene for Tangier's Disease, which was later confirmed. This was listed as the American Heart Association's Discovery of the Year for 1999.

Research Associate, Roche Molecular Systems (1997-1998)

Development of technologies to identify viruses in human plasma based on their DNA content. This is the laboratory in which PCR was invented by Kary Mullis (who won the Nobel Prize for it in 1993), and provided me with a skill set that has been invaluable.

Research Associate, University of Ottawa Heart Institute (1994-1997)

Assess the expression of genes in human tissues affected by cardiovascular disease. I participated in the development of many molecular biology techniques as that field was first being developed.

Research Associate, University of Washington, Department of Pathology (1991-1994)

Development of animal models to uncover the mechanism of restenosis after balloon angioplasty. This work was followed up with work with stents, which is currently the therapy of choice for many patients with coronary artery disease.

Awards and Patents

Winner of the Aquaculture Genome Funding Competition 2014

Winner of the Genome Prize, University of Alaska Fairbanks 2012

Rasmuson Fellow 2011

Rasmuson Fellow 2010

Winner of the Center for Arctic Change and Global Research Award 2010

Winner of the Experimental Program to Stimulate Cooperative

Research (EPSCoR) Award 2005

Awarded Patent 6835563

Compositions and methods for increasing cholesterol efflux

and raising HDL ATP binding cassette transporter protein ABC1 2004

*I am currently living in Haifa Israel. I've provided my cel number but it may be best to contact me via email or SKYPE.

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