Publications I. Manov

PhD Thesis: Population and genetic analysis of antigenic variants of Influenza A (H3N2) viruses (1988) [Russian]. Institute of Influenza, Russian Academy of Medical Sciences, St. Petersburg, Russia.

Refereed Papers in Professional Journals
1. Kolotvinov S.V., Manova I.P., Galitarov S.S., and Sukhinin V.P (1987) Structural characteristics of a population of antigenic variants of the influenza A (H3N2) virus. Voprosi Virusologii (Moscow), 32(4): 409-13 [Russian]

2. Manova I. P., and Kolotvinov S.V. (1989) Investigation of the genetic markers of the influenza viruses. Genetics of viruses, (Leningrad); 19: 78-81 [Russian]

3. Kolotvinov S.V., Manova I.P., Podcherniaeva R.Y., Akhmetova L.I., Elkin V., Berezin V., Zhilinskaia I.N., and Grigoriev V. (1990) Study of influenza A virus hemagglutinin H3 avidity using monoclonal antibodies, Voprosi Virusologii (Moscow), 35(1): 13-6 [Russian]

4. Kolotvinov S.V., Akhmetova L.I., Manova I.P., and Galitarov S.S. (1990). The heterogeneity of an influenza A population in its capacity to induce the synthesis of avid antibodies. Voprosi Virusologii (Moscow), 35: 367-70. [Russian]

5. Manova I.P., Kolotvinov S.V., Zhilinskaia I.N., and Sukhinin V.P. (1990). Isolation and comparative study of highly reproductive recombinant influenza A viruses with high antibody sensitivity. Voprosi Virusologii (Moscow), 35(6): 458-61. [Russian]

6. Mandel H., Hartman C., Bercowitz D., Elpeleg O.N., Manov I., and Iancu T.C. (2001) The hepatic mitochondrial DNA depletion syndrome: ultrastructural changes in liver biopsies. Hepatology 34: 776-84

7. Manov I., Hirsh M., and Iancu T.C. (2002) Acetaminophen hepatotoxicity and mechanisms of its protection by N-acetylcysteine: a study of Hep3B cells. Experimental and Toxicologic Pathology 53(6): 489-500

8. Munichor M., Cohen H., Sarid R., Manov I., and Iancu T.C (2004). Human herpesvirus 8 inclusions in primary effusion lymphoma in an HIV-seronegative male. Acta Cytologica48(3): 425-30

9. Manov I., Hirsh M., and Iancu T.C. (2004) N-acetylcysteine does not protect HepG2 cells against acetaminophen-induced apoptosis. Basic & Clinical Pharmacology & Toxicology 94(5): 213-25

10. Levanon D., Manov I., and Iancu T.C. (2004) Qualitative and quantitative analysis of the effects of acetaminophen and N-acetylcysteine on the surface morphology of Hep3B hepatoma cells in vitro. Ultrastructural Pathology 28(1): 3 -14

11. Manov I., Bashenko Y., Hirsh M., and Iancu T.C. (2006) Involvement of the multidrug resistance P-glycoprotein in acetaminophen-induced toxicity in hepatoma-derived HepG2 and Hep3B cells. Basic & Clinical Pharmacology & Toxicology 99(3):213 –224

12. Manov I, Motanis H, Frumin I, Iancu TC. Hepatotoxicity of anti-inflammatory and analgesic drugs: ultrastructural aspects. Acta Pharmacologica Sinica 2006; 27: 259-272. (invited review).

13. Iancu T.C., Mahajnah M., Manov I, Cherurg S., Knopf C., and Mandel H. (2007) The liver in congenital disorders of glycosylation: ultrastructural features. Ultrastructural Pathology 31(3):189-97

14. Iancu T.C., Mahajnah M., Manov I., and Shaoul R. (2007) Microvillous inclusion disease: ultrastructural variability. Ultrastructural Pathology 31(3):173-88

15. Bar A., Riskin A., Iancu T., Manov I., Arad A., and Shaoul R. (2007) A newborn infant with protracted diarrhea and metabolic acidosis. Journal of Pediatrics 150(2):198-201

16. Hirsh M.I., Manov I., Cohen-Kaplan V., and Iancu T.C. (2007) Ultrastructural features of lymphocyte suppression induced by anthrax lethal toxin and treated with chloroquine. Laboratory Investigation 87(2):182-8

17. Manov I., Bashenko Y., Eliaz-Wolkowicz A., Mizrahi M., Liran O., and Iancu T.C. (2007) High-dose acetaminophen inhibits the lethal effect of doxorubicin in HepG2 cells: the role of P-glycoprotein and mitogen-activated protein kinase p44/42 pathway. Journal of Pharmacology and Experimental Therapeutics 322(3):1013-22

18. Rott R., Szargel R., Haskin J., Shani V., Shainskaya A., Manov I., Liani E., Avraham E., and Engelender S. (2008) Monoubiquitylation of alpha-synuclein by seven in absentia homolog (SIAH) promotes its aggregation in dopaminergic cells. Journal of Biological Chemistry 283(6):3316-28

19. Iancu T.C., and Manov I. (2010) Ultrastructural aspects of enterocyte defects in infancy and childhood. Ultrastructural Pathology 34(3):117-25

20. Manov I., Pollak Y., Broneshter R., and Iancu T.C. (2011) Inhibition of doxorubicin- induced autophagy in hepatocellular carcinoma Hep3B cells by sorafenib – the role of extracellular signal-regulated kinase counteraction. FEBS Journal 278(18) 3494–507

21. Asleh R., Nakhoul F.M., Miller-Lotan R., Awad H., Farbstein D., Levy N.S., Nakhoul N., Iancu T.C., Manov I., Laue M., Traber M.G., Lebold K.M., and Levy A.P. (2012) Poor lysosomal membrane integrity in proximal tubule cells of haptoglobin 2-2 genotype mice with diabetes mellitus. Free Radical Biology & Medicine 53(4):779-86

22. Klionsky D.J., Abdalla F.C., Abeliovich H., Abraham R. T., Manov I., et al. (2012) Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy8(4):445-544 (review)

23. Pollak Y., Mechlovich D., Amit T., Bar-Am O., Manov I., Mandel S.A., Weinreb O., Meyron-Holtz E.G., Iancu T.C., and Youdim M.B. (2013). Effects of novel neuroprotective and neurorestorative multifunctional drugs on iron chelation and glucose metabolism. Journal of Neural Transmission 120 (1):37–48

24. Shams I., Malik A., Manov I., Joel A., Band M., and Avivi A. (2013) Transcription pattern of p53-targeted DNA repair genes in the hypoxia-tolerant subterranean mole rat Spalax. Journal of Molecular Biology 425(7):1111-8

25. Iancu T.C., Manov I., Shaoul R., Haimi M., and Lerner A. (2013) What's in a name?- "Lipolysosome": ultrastructural features of a lipid-containing organelle. Ultrastructural Pathology 37(5):293-303

26. Sarig O., Goldsher D., Nousbeck J., Fuchs-Telem D., Cohen-Katsenelson K., Iancu T.C., Manov I., Saada A., Sprecher E., and Mandel H. (2013). Infantile mitochondrial hepatopathy is a cardinal feature of MEGDEL syndrome (3-Methylglutaconic aciduria type IV with sensorineural deafness, encephalopathy and leigh-Like Syndrome) caused by novel mutations in SERAC1. American Journal of Medical Genetics Part A 61(9): 2204-15

27. Manov I., Hirsh M., Iancu T.C., Malik A., Sotnichenko N., Band M., Avivi A., and Shams I. (2013) Pronounced cancer resistance in a subterranean rodent, the blind mole- rat, Spalax: in vivo and in vitro evidence. BMC Biology 11:91: 1-17

28. Iancu T.C., Arad T., Avivi A, Shams I and Manov I. (2014) Iron-rich ferritin in the hypoxia-tolerant blind mole rat Spalax ehrenbergi: an in-vivo natural marker confirms internalization and pathways of intracellular macromolecules. Journal of Structural Biology 187(3):254-265

29. Domankevich V, Opatowsky Y, Malik A, Korol AB, Frenkel Z, Manov I, Avivi A, Shams I (2016) Adaptive patterns in the p53 protein sequence of the hypoxia- and cancer-tolerant blind mole rat Spalax.
BMC Evol Biol. 2016 Sep 2;16:177

30.Mamchur A, Leman E, Salah S, Avivi A, Shams I, Manov I. Adipose-Derived Stem Cells of Blind Mole Rat Spalax Exhibit Reduced Homing Ability: Molecular Mechanisms and Potential Role in Cancer Suppression. Stem Cells. 2018 Oct;36(10):1630-1642

31. Altwasser R, Paz. A, Korol, Manov I, Avivi A, Shams, I. (2019) The transcriptome landscape of the carcinogenic treatment response in the blind mole rat: insights into cancer resistance mechanisms. BMC Genomics. 2019 Jan 8;20(1):17

32. Adwan Shekhidem H, Sharvit L, Leman E, Manov I, Roichman A, Holtze S, M Huffman D, Y Cohen H, Bernd Hildebrandt T, Shams I, Atzmon G. (2019) Telomeres and Longevity: A Cause or an Effect. Int J Mol Sci. 2019 Jul 1;20(13)

Chapters in Scientific Books
Iancu T. C., and Manov I. (2011) Electron Microscopy of Liver Biopsies, Book chapter in: Liver Biopsy, Edited by: Hirokazu Takahashi, pp. 109- 136, InTech, 978-953-307-644-7, Croatia