Publications A. Avivi

For complete list of publications see here:

List of Publications on Hypoxia and Cancer:

Avivi, A., Resnik, M.B., Joel, A., Nevo, E., Levi, A.P. (1999) Adaptive hypoxic tolerance in the subterranean mole rat, Spalax ehrenbergi: The role of VEGF. FEBS Letters 452: 133-140.

Melamed-Frank, M., Terzic, A., Carrasco, A.J., Nevo, E., Avivi, A., Levy, A.P. (2001) Reciprocal regulation of expression of pore-forming KATP channel genes by hypoxia. Mol. Cell. Biol. 225: 145-150.

Roguin, A*. Avivi, A,*, Nitecki, S., Levy, N.S., Resnick, M.B, Hofman, A., Nevo, E., and Levy, A.P. (2003) Successful restoration of blood flow using continuous infiltration of plasmid DNA encoding mole rat VEGF. Proc. Natl. Acad. Sci. USA 100: 4644-4648.

(* Equal Contribution)

Schmidt, M., Gerlach, F., Avivi, A., Laufs, T., Wystub, S., Simpson, J.C., Nevo, E.,Saaler-Reinhardt, S., Reuss, S., Hankeln, T., Burmester, T. (2004) Cytoglobin is a respiratory protein in connective tissue and neurons that is up-regulated by hypoxia. J. Biol. Chem. 279: 8063-8069.

Roguin, A., Nitecki, S., Rubinstein, I., Abassi, Z.A., Sabo, E., Levy, N.S., Nevo, E., Avivi, A., Lache, O., Frank, M., Hoffman, A., Levy, A.P. (2003) Vascular endothelial growth factor (VEGF) fails to improve blood flow and promote collateralization in a diabetes model of hindlimb ischemia. Cardiovasc Diabetol. 2: 18-23.

Shams, I., Avivi, A.,* Nevo, E.* (2004) Hypoxic stress tolerance of the subterranean mole rat: expression of erythropoietin and hypoxia-inducible factor -1α .Proc. Natl. Acad. Sci. USA 101: 9698-9703.

(* Joint senior authorship)

Ashur-Fabian, O.*, Avivi, A., * Trakhtenbrot, L., Adamsky, K., Cohen, M., Kajakaro, G., Joel, A., Amariglio, N., Ninette, Nevo, E., Rechavi, G. (2004) Evolution of p53 in hypoxia-stressed Spalax mimics human tumor mutation. Proc. Natl. Acad. Sci. USA 101: 12236-12241.

(* Equal Contribution)

Shams, I., Nevo, E. Avivi, A. (2005) Ontogenetic expression of erythropoietin and hypoxia-inducible factor -1 alpha genes to hypoxia in subterranean blind mole rat. FASEB J. 19: 307-309.

Hankeln, T., Ebner, B., Fuchs, C. Gerlach, F., Haberkamp, M., Laufs, T., Roesner, A., Schmidt, M., Weich, B., Wystub, S., Saaler-Reinhardt, S., Reuss, S., Bolognesi, M., De Sanctis, D., Marden, M.C., Kiger, L., Dewilde, S., Moens, L., Nevo, E., Avivi, A., Weber, R. E., Fago, A., Burmester, T. (2005) Neuroglobin and cytoglobin in search of their role in the vertebrate globin family. J. Inorg. Biochem. 99: 110-119.

Shams, I.,* Avivi, A,, Nevo, E., Ivanitskaya, E.* (2005) Assignment of erythropoietin to blind subterranean mole rat chromosome 1q by in situ hybridization. Cytogenet. Genome Res. 108: 362D.

(* Equal Contribution)

Avivi, A., Ashur-Fabian, O., Amariglio, N., Nevo, E., Rechavi, G. (2005) p53- A key player in tumoral and evolutionary adaptation: A lesson from the Israeli blind subterranean mole rat. Cell Cycle 4: 368-372. (Invited Review)

Avivi, A.,* Shams, I.,* Joel, A., Lache, O., Levy, A.P., Nevo, E.(2005) Increased blood vessel density provides the mole rat physiological tolerance to its hypoxic subterranean habitat. FASEB J. 19: 1314-1316.

(* Equal Contribution)

Shams, I., Nevo, E., Avivi, A. (2005) Differential expression of two erythropoietin receptor forms in blind subterranean mole rat. FASEB J. 19: 1749-1751.

Nasser, N., Nevo, E., Shafat, I., Ilan, I., Vlodavsky, I., Avivi, A. (2005) Adaptive evolution of heparanase in hypoxia-tolerant Spalax: novel splice variant. Proc. Natl. Acad. Sci. USA 102: 15161-15166.

Shams, I., Avivi, A.,* Nevo, E. (2005). Adaptation of blind mole rats to life underground: O2 and CO2 Fluctuations in Burrows Comp. Biochem. Physiol. 142: 376-382.

(* Joint senior authorship)

Brodsky, L., Jacob-Hirsh, J., Avivi, A., Band, M., Trakhtenbrot, L., Zeligson S., Amariglio, N., Paz, A, Korol, A. Rechavi, G. Nevo, E. (2005) Evolutionary regulation of the blind subterranean mole rat, Spalax, revealed by microarray gene expression analysis. Proc. Natl. Acad. Sci. USA 102: 17047-17052.

Caballero, B., Tomas-Zapico, C., Joel, A., Nevo, E., Avivi, A.,* Coto-Montes, A.* (2006) Antioxidant activity in the harderian glands of the blind subterranean Spalax ehrenbergi: A possible adaptation to underground stresses. J. Comp. Physiol. - A 192: 753-759.

(* Joint senior authorship)

Avivi, A., Brodsky, L., Nevo,E., Band, M.R. (2006) Comparative gene expression between two ecologically different species of the hypoxia-tolerant blind subterranean mole rat Spalax ehrenbergi. Physiol. Genomics. 27: 54-64.

Nasser, N, Avivi, A,* Shushy, M., Vlodavsky, I. and Nevo, E. (2007) Cloning, expression and characterization of an alternatively spliced variant of human heparanase. Biochem. Biophys. Res. Comm. 354: 33–38.

(*Corresponding Author)

Avivi, A., Ashur-Fabian, O., Joel, A., Trakhtenbrot, L., Adamsky, K., Goldstein, I., Amariglio, N., Rechavi, G., Nevo, E. (2007) P53 in blind subterranean mole rats– loss of function versus gain of function activities on newly cloned Spalax target genes. Oncogene 26: 2507-2512.

Ravid, OΩ., Shams, I. Ω, Ben Califa, N. , Nevo, E., Avivi, A., * Neumann, D. * (2007) An extracellular region of the erythropoietin receptor of the subterranean blind mole rat Spalax enhances receptor maturation. Proc. Natl. Acad. Sci. USA 104: 114360–14365.

(* Joint senior authorship) (Ω Equal contribution)

Band, M., * Shams, I., * Joel, A., Avivi, A. (2008)Cloning and in vivo expression of vascular endothelial growth factor receptor 2 (Flk1) in the naturally hypoxia-tolerant subterranean mole rat. FASEB J. 22: 105-112.

(* Equal Contribution)

Gerlach, F., Avivi, A., Joel, A., Burmester, T., Nevo, E., Hankelen, T. (2007) Genomic organization and molecular evolution of the genes for neuroglobin and cytoglobin in the hypoxia-tolerant Israeli mole rat, Spalax carmeli. Isr. J. Ecol. Evol. 52: 389- 403.

Avivi, A., Band, M., Joel, A., Shenzer, P., Coleman, R. (2008) Adaptive features of skeletal muscles of mole rats (Spalax ehrenbergi) to intensive activity under subterranean hypoxic conditions. Acta Histol. 111: 415-419.

Sandwall, E., Bodevin, S., Nasser, N.J., Nevo, E., Avivi, A., Vlodavsky, I., Li1, J-P (2008). Molecular structure of heparin sulfate from Spalax. Implications of heparanase and hypoxia. J. Biol. Chem. 284:3814-3822.

Band, M., Joel, A., Hernandez, A., Avivi, A. (2009). Hypoxia-induced BNIP3 expression and mitophagy in the hypoxia-tolerant subterranean mole rat, Spalax: A pioneering in vivo study. FASEB J. 23: 2327-2335.

Nasser, N.J.,* Avivi, A.,* Shafat, I., Edovitsky, E., Zcharia, E., Ilan, N., Vlodavsky. I., Nevo E. (2009). Alternatively spliced Spalax heparanase inhibits extracellular matrix degradation, tumor growth, and metastasis. Proc. Natl. Acad. Sci. USA 106: 2253-2258.

(* Equal Contribution)

Nasser, N.J., Kaplan, M., Avivi, A., Nevo, E., Aviram, M. (2009) Lipid profile and serum characteristics of the blind subterranean mole rat, Spalax. PLoS One. 4(2): e4528.

Band, M., Joel. A., Avivi, A (2010). The muscle ankyrin repeat proteins are hypoxia-sensetive: In vivo expression in the hypoxia-tolerant blind subterranean mole rat, Spalax ehrenbergi. J. Mol. Evol. 70: 1-12.

Soria-Valles, C., Caballero, B., Vega-Naredo, I., Sierra, V., Huidobro-Fernández, C., Gonzalo-Calvo, D.D, Tolivia, D., Rodríguez-Colunga, M.J., Joel, A., Coto-Montes, A., Avivi, A. (2010) Antioxidant response to variations of oxygen in Harderian gland of different species of Spalax. Can. J. Zool. 88: 803-807.

Band, M., Ashur-Fabian, O., Avivi, A. (2010). The expression of p53-target genes in the hypoxia-tolerant subterranean mole-rat is hypoxia-dependent and similar to expression patterns in solid tumors. Cell Cycle 9: 3347-3352.

Avivi, A., Gerlach, F., Joel, A., Reuss, S., Burmester, T., Nevo, E., Hankeln, T. (2010) Neuroglobin, cytoglobin and myoglobin contribute to the hypoxia-adaptation of the subterranean mole rat Spalax. Proc. Natl. Acad. Sci. USA 107: 21570-21575.

Malik, A., Frenkel, Z., Hernandez, A., Band, M., Nevo,E., Avivi, A. (2011) Characterization of inbreeding avoidance levels and paternity relationships in mole rat Spalax ehrenbergi by microsatellite genotyping. Popul. Ecol 53: 501-511.

Malik, A., Korol, A., Glaser, F., Paz, A., Hubner, S., Hernandez, A.G., Thimmapuram, J., Shahjahan Ali, S., Avivi, A.,* Band, M. * (2011) Transcriptome sequencing of the blind subterranean 1 mole rat, Spalax galili: utility and potential for the discovery of novel evolutionary patterns. PloS One 8: e21227.

(* Joint senior authorship)

Moskovitz, J., Malik, A., Hernandez, A., Band,M., Avivi, A. (2011) Methionine sulfoxide reductases and methionine sulfoxide in the Subterranean Mole Rat (Spalax): characterization of expression under various oxygen condition. Comp. Biochem. Physiol. (part A) 161: 406-414.

Schülke S., Dreidax D., Nevo E., Burmester T., Band M., Avivi A. *, Hankeln T.*(2012) Stressful times: expressional characterisation of the antioxidant defence in the subterranean mole rat, Spalax. Gene 500: 199-206.

(* Joint senior authorship)

Band, M., Malik, A., Joel, A., Avivi, A. (2012) Oxygen sensitivity of the brain NMDA receptor-2 subunit composition and hypoxia-tolerance: A developmental study of the subterranean mole rat, Spalax. J. Comp. Physiol. 182 (7): 961-969.

Yakushev, S., Band, M., Tissot van Patot, M., Gassmann, M., Avivi, A.,* Bogdanova, A.*. (2012) Cross-talk between S-nitrosylation and S-glutathionylation in control of the Na,K-ATPase regulation in hypoxic heart. Am. J. Physiol. Heart Circ. 303: H1332-H1343.

(* Joint senior authorship)

Malik, A., Korol, A., Weber, M., Hankeln, T., Avivi, A.,* Band, M.* (2012) Transcriptional responses underlying hypoxia and cancer tolerance in Spalax. BMC Genomics (on line)

Shams, I., Malik, A., Manov, I., Joel, A., Band, M., Avivi, A. (2013) Expression of p53-targeted DNA repair genes in the hypoxia-tolerant subterranean mole-rat, Spalax. J. Mol. Biol. 425: 1111-1118.

Manov, I., Hirsh, M., Iancu, T.C., Malik, A., Sotnichenko, N., Band, M., Avivi, A.,* Shams, I. * (2013) Pronounced cancer resistance in a subterranean rodent, the blind mole-rat, Spalax: In vivo and in vitro Evidence. BMC Biol. 11 :91.

(* Joint senior authorship)

Avivi, A., Nevo, E., Cohen, K., Sotnichenko, N., Hercbergs, A., Band, M., Davis, P.J., Ellis, E., and Ashur-Fabian, O. (2013). They live in the land down under: thyroid function and basal metabolic rate in the blind mole rat, Spalax. Endocr. Res. 39(1): 80-85.

Fang, X.,* Nevo, E.,* Han, L.,* Avivi, A.,*, Levanon, E.Y.,* Zhao, J.,* Larkin, D..., Shams, I., ...Hankeln, T.,... Band, M.,... et al. (2014). Genome-wide adaptive complexes to underground stresses in blind mole rats Spalax. Nat Commun. 5:3966. doi: 10.1038/ncomms4966.

(* Joint 1st author)

Schmidt, H., Hangmann, J., Shams, I., Avivi, A., Hankeln, T. (2015) Molecular evolution of antioxidant and hypoxia response in long-lived, cancer-resistant blind mole rats: The Nrf2-Keap1 pathway. Gene. ,577(2):293-298

Domankevich, V., Opatowsky, Y., Malik, A. , Korol, A. , Frenkel, Z. , Manov, I. , Avivi, A., and Shams, I. (2016). Adaptive patterns in the p53 protein sequence of the hypoxia- and cancer-tolerant blind mole rat Spalax. BMC Evol. Biol., 16:177. doi: 10.1186/s12862-016-0743-8.

Malik, A., Domankevich, V., Lijuan, H,. Xiaodong, F., Korol, A., Avivi, A.Shams, I. (2016). Genome maintenance and bioenergetics of the long-lived hypoxia-tolerant and cancer-resistant blind mole rat, Spalax: a cross-species analysis of brain transcriptome. 
Nature Sci. Reports, 6:38624. doi: 10.1038/srep38624

Schmidt, H., Malik, A., Bicker, A., Poetzsch, G., Avivi, A., Shams, I., Hankeln, T. (2017)
Hypoxia tolerance, longevity and cancer-resistance in the mole rat Spalax - a liver transcriptomics approach.
Nature Sci. Reports 0;7(1):14348. doi: 10.1038/s41598-017-13905-z.

Mamchur, A., Leman, E., Salah, S., Avivi, A., Shams, I., Manov, I. (2018). Adipose-Derived Stem Cells of Blind Mole Rat Spalax Exhibit Reduced Homing Ability: Molecular Mechanisms and Potential Role in Cancer Suppression. Stem Cells. 2018 Oct;36(10):1630-1642. doi: 10.1002/stem.2884.

Altwasser, R., Paz, A., Korol, A., Manov, I, Avivi, A., Shams, I. (2019)
The transcriptome landscape of the carcinogenic treatment response in the blind mole rat: insights into cancer resistance mechanisms.
BMC Genomics. 8;20(1):17. doi: 10.1186/s12864-018-5417-z.