Irena Manov M.D., Ph.D.

Manov tmuna  
Associate Professor
Office: Multi-Purpose Building, Room 149 | Phone: 972-4-8249-972 | Fax: 972-4-8288-235
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Subject: Evolution and cancer: tumor suppressive mechanisms in hypoxia-tolerant subterranean mole rat, Spalax
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Research Interests

Mechanisms of cancer resistance in hypoxia-tolerant subterranean rodents;

• Autophagy and lifespan in rodent;

• Molecular mechanisms regulating anticancer drug resistance;

• Iron homeostasis and storage in hypoxia-tolerant mammals. Regulation of ferritin synthesis under environmental stress;

• Hepatotoxicity of anti-inflammatory and anticancer drugs: molecular and ulatrastructural aspects.

Selected Publications

Manov I, Bashenko Y, Hirsh M, Iancu TC. Involvement of the multidrug resistance P-glycoprotein in acetaminophen-induced toxicity in hepatoma-derived HepG2 and Hep3B cells. Basic & Clinical Pharmacology & Toxicology 2006; 99:213-224.

Manov I, Motanis H, Frumin I, Iancu TC. Hepatotoxicity of anti-inflammatory and analgesic drugs: ultrastructural aspects. Acta Pharmacologica Sinica 2006; 27: 259-272. (Invited review). http://www.ncbi.nlm.nih.gov/pubmed/1649016

Hirh MI, Manov I, Cohen-Kaplan V. Iancu TC. Ultrastructural features of lymphocyte suppression induced by anthrax lethal toxin and treated with chloroquine. Laboratory Investigation 2007; 87(2): 182-188. http://www.ncbi.nlm.nih.gov/pubmed/1717

Manov I, Bashenko Y, Eliaz-Wolkowicz A, Mizrahi M, Liran O, Iancu TC. High-dose acetaminophen inhibits the lethal effect of doxorubicin in HepG2 cells: the role of P-glycoprotein and mitogen-activated protein kinase p44/42 pathway. Journal of Pharmacology and Experimental Therapeutics 2007; 322(3): 1013-1022.

Iancu T.C. and Manov I. Ultrastructural Aspects of Enterocyte Defects in Infancy and Childhood. Ultrastructural Pathology 2010; 34: 1-9. http://www.ncbi.nlm.nih.gov/pubmed/20455660

Manov I, Pollak Y, Broneshter R and Iancu T.C. Inhibition of doxorubicin-induced autophagy in hepatocellular carcinoma Hep3B cells by sorafenib - the role of extracellular signal-regulated kinase counteraction. FEBS Journal 2011; 278: 3494-3507. http://www.ncbi.nlm.nih.gov/pubmed/21790999

Manov I., Hirsh M., Iancu T.C., Malik A., Sotnichenko N., Band M., Avivi A., and Shams I. Pronounced cancer resistance in a subterranean rodent, the blind mole-rat, Spalax: in vivo and in vitro evidence. BMC Biology 2013, 11:91: 1-17. http://www.ncbi.nlm.nih.gov/pubmed/25050761

Iancu T.C., Arad T., Avivi A, Shams I and Manov I. Iron-rich ferritin in the hypoxia-tolerant blind mole rat Spalax ehrenbergi: an in-vivo natural marker confirms internalization and pathways of intracellular macromolecules. Journal of Structural Biology 2014, 187(3):254-65. http://www.ncbi.nlm.nih.gov/pubmed/25050761

Book Chapter: Iancu T. C. and Manov I. Electron Microscopy of Liver Biopsies, In: Liver Biopsy, Edited by: Hirokazu Takahashi, pp. 109- 136, InTech, 2011; 978-953-307-644-7, Croatia.
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