Pawel Michalak

Research Interests

Associate Professor at Edward Via College of Osteopathic Medicine, focusing on comparative genomics, bioinformatics, and evolution. His team has employed an integrative approach with a variety of molecular, computational and modeling techniques, including NextGen sequencing of entire genomes, epigenomes, and transcriptomes to rigorous understanding how complexity elaborates from genomes through gene regulatory networks, and how it evolves over generations in response to environmental stress and intragenomic challenges. He worked in nine universities in four countries across three continents. His research resulted in a book (another is in preparation), multiple book chapters, and about 50 peer-reviewed papers in scientific journals, including “Science”, “Nature”, “Proceedings of the National Academy of Sciences USA”, and “Proceedings of the Royal Society”, already cited about 1,300 times and popularized by various public media.

Selected Publications

Yablonovitch AL, Fu J, Li K, Mahato S, Kang L, Rashkovetsky E, Korol AB, Tang H, Michalak P, Zelhof AC, Nevo E, Li JB. Regulation of gene expression and RNA editing in Drosophila adapting to divergent microclimates.  Nat Commun. 2017 Nov 17;8(1):1570.

Keane M, Semeiks J, Webb AE, et al. Insights into the evolution of longevity from the bowhead whale genome. Cell Rep. 2015;10:112-122.

Dittmar WJ, McIver L, Michalak P, Garner HR, Valdez G. EvoCor: a platform for predicting functionally related genes using phylogenetic and expression profiles. Nucleic Acids Res. 2014;42:W72-5.  

Kim YB, Oh JH, McIver LJ, et al. Divergence of Drosophila melanogaster repeatomes in response to a sharp microclimate contrast in Evolution Canyon, Israel. Proc Natl Acad Sci U S A. 2014;111:10630-10635.  

Hubner S, Rashkovetsky E, Kim YB, et al. Genome differentiation of Drosophila melanogaster from a microclimate contrast in Evolution Canyon, Israel. Proc Natl Acad Sci U S A. 2013;110:21059-21064.  

Malone JH, Michalak P. Physiological sex predicts hybrid sterility regardless of genotype. Science. 2008;319:59.  

Michalak P, Minkov I, Helin A, et al. Genetic evidence for adaptation-driven incipient speciation of Drosophila melanogaster along a microclimatic contrast in "Evolution Canyon," Israel. Proc Natl Acad Sci U S A. 2001;98:13195-13200.  

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